ADAR
ADAR
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Investments List
| Date | Company | Article | Money raised |
|---|---|---|---|
| 2023-03-05 | Click-Ins | Adar investment in Venture Round - Click-Ins | 7.5 M USD |
More informations about "Adar"
ADAR Family Proteins: A Structural Review - MDPI
Apr 26, 2024 This review aims to highlight the structures of ADAR proteins that have been crucial in the discernment of their functions and are relevant to future therapeutic development. ADAR proteins can correct or diversify genetic …See details»
The ADAR protein family | Genome Biology | Full Text - BioMed …
Domain organization of ADAR and ADAD proteins …
Domain organization of ADAR and ADAD proteins expressed in Homo sapiens . All of the proteins contain N-terminal dsRBDs and C-terminal deaminase domains. An arginine rich (R) region is present at ...See details»
How do ADARs bind RNA? New protein-RNA structures illuminate …
Our recent publication of X-ray crystal structures of human ADAR2 deaminase domain (hADAR2d) bound to dsRNA provided an opportunity to understand ADAR’s flipping …See details»
ADAR1: from basic mechanisms to inhibitors - Cell Press
Jul 18, 2024 Adenosine deaminase acting on RNA 1 (ADAR1) converts adenosine to inosine in double-stranded RNA (dsRNA) molecules, a process known as A-to-I editing. ADAR1 deficiency in humans and mice results in …See details»
ADAR Proteins: Double-stranded RNA and Z-DNA Binding …
Fig. 2 Domain organization of the ADAR family members. a The ADAR family members are represented with their domain structure organization. Three ADARs are found in vertebrates …See details»
Activity Regulation of Adenosine Deaminases Acting on RNA …
Nov 20, 2011 Genomic organization of human ADAR genes. Exons are represented to scale by boxes; introns, not to scale, by lines.Filled boxes are coding, and open boxes are non-coding; …See details»
Identification of ADAR1 adenosine deaminase …
Dec 21, 2018 To establish a mechanistic link between PKR and ADAR1 dependency, we deleted PKR in ADAR KO-sensitive HCC366 and NCI-H1650 cells prior to ADAR deletion (Supplementary Fig. 5c).See details»
Structures of human ADAR2 bound to dsRNA reveal …
Apr 11, 2016 These structures, together with structure-guided mutagenesis and RNA-modification experiments, explain the basis of the ADAR deaminase domain's dsRNA specificity, its base-flipping mechanism, and ...See details»
Adenosine Deaminase Acting on RNA (ADAR) Enzymes: …
Nov 1, 2023 ConspectusThe adenosine deaminase acting on RNA (ADAR) enzymes that catalyze the conversion of adenosine to inosine in double-stranded (ds)RNA are evolutionarily conserved and are essential for many biological …See details»
Functions of the RNA Editing Enzyme ADAR1 and Their Relevance …
The general structure of ADAR enzymes involves two to three dsRNA binding motifs, and a catalytic deaminase domain at the C terminus. In vertebrates, three types of ADARs have …See details»
Adenosine deaminase acting on RNA (ADAR1), a suppressor of …
ADAR enzymatic activity was purified and characterized from bovine nuclear extracts and from cultured HeLa cells . The findings, described in JBC, revealed that the nuclear dsRNA …See details»
Purification and assay of ADAR activity - PubMed
ADAR editing enzymes are found in all multicellular animals and are conserved in sequence and protein organization. The number of ADAR genes differs between animals, ranging from three …See details»
Dissecting the basis for differential substrate specificity of ADAR1 ...
Dec 11, 2023 Millions of adenosines are deaminated into inosines transcriptome-wide 1,2, catalyzed by two deaminating enzymes, ADAR1 (ADAR) and ADAR2 (ADARB1).Inosine is …See details»
Origins and evolution of ADAR-mediated RNA editing - IUBMB
May 26, 2009 Recent reviews on RNA editing have been elaborated on the ADAR gene organization, molecular mechanism, biological significance, and evolution in chordate and …See details»
About — Adar Cohen
Adar Cohen leads conversations in conflict zones, family rooms, and other places where people can save the world. His work has been featured by the New York Times, TED, TED Ideas, …See details»
Site-directed RNA editing by harnessing ADARs: advances and
Adenosine deaminase acting on RNA (ADAR) enzyme–mediated A-to-I RNA editing is widely distributed in the transcriptome. It plays an important role in autoimmune surveillance, …See details»
High-throughput mutagenesis reveals unique structural features …
Oct 12, 2020 ADAR activity is required for nervous system function and altered editing has been linked to neurological disorders 8,9,10. Furthermore, ADAR1 plays an important role in innate …See details»
Adar RNA editing-dependent and -independent effects are
Mar 27, 2020 The Adar gene is on the first (or X) chromosome and we confirmed that RNA editing was eliminated by sequencing of total, ribosome-depleted head RNA of male Adar …See details»