BH3
BH3 Management, a vertically integrated real estate investor, operator, and developer founding in 2009
BH3
Industry:
Commercial Real Estate Construction Lending Real Estate Investment
Founded:
2009-10-01
Status:
Active
Contact:
954-416-3140
Email Addresses:
[email protected]
Technology used in webpage:
Domain Not Resolving CrUX Dataset CrUX Top 10m Gravity Forms
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Current Employees Featured
Founder
Investments List
| Date | Company | Article | Money raised |
|---|---|---|---|
| 2023-07-11 | CarbonCure Technologies | BH3 investment in Venture Round - CarbonCure Technologies | 80 M USD |
| 2017-11-07 | Gridics | BH3 investment in Seed Round - Gridics | 1.6 M USD |
More informations about "BH3"
BH3 Mimetics for the Treatment of B-Cell …
Mechanism of action of BH3 mimetics. (A) Pro-survival proteins (e.g., BCL2, B-cell lymphoma extra large [BCLxL], myeloid cell leukemia 1 [MCL1]), shown in blue, are commonly overexpressed in cancer cells, where they sequester high …See details»
BH3-Triggered Structural Reorganization Drives the …
Nov 12, 2010 BAX is a proapoptotic BCL-2 family member that lies dormant in the cytosol until converted into a killer protein in response to cellular stress. Having recently identified the elusive trigger site for direct BAX activation, we …See details»
Structural Details of BH3 Motifs and BH3-Mediated Interactions: …
May 24, 2022 Experimentally validated BH3 motifs from human proteins. We included all members of the BCL2 family (both anti-apoptotic and pro-apoptotic) and BH 3-containing …See details»
BH3 Protein - an overview | ScienceDirect Topics
A BH3 protein is defined as a type of protein that contains BH3 motifs which bind and regulate Bcl-2 homologs, playing a crucial role in cellular responses to stress-induced cues and cell …See details»
BH3 mimetics targeting BCL-XL have efficacy in solid tumors
16 hours ago BH3 mimetic drugs that inhibit BCL-2, BCL-XL, or MCL-1 have limited activity in solid tumors. ... evidence that nuclear organization contributes to the efficient activation and …See details»
BH3-only proteins: a 20-year stock-take - FEBS Press
Jan 6, 2015 BH3-only proteins are the sentinels of cellular stress, and their activation commits cells to apoptosis. Since the discovery of the first BH3-only protein BAD almost 20 years ago, at least seven more BH3-only proteins have …See details»
BH3-only proteins in apoptosis and beyond: an …
The first evidence for functional diversity within the BH3 domain came from an in vitro functional analysis of the BH3-domain-containing peptides derived from different BH3-only proteins to induce mitochondrial release of cytochrome c in …See details»
Collaborative orchestration of BH3-only proteins governs Bak/Bax ...
Feb 25, 2025 BH3-only proteins, including Bid, Bim, Puma, Noxa, Bad, Bmf, Bik and Hrk, serve as apoptosis initiators. They are activated by various stimuli, which leads to Bak/Bax …See details»
BH3 domains: intracellular death-ligands critical for initiating ...
Sep 1, 2002 Certain BH3-only proteins display selective binding to specific BCL-2 family members. For example, BID binds to both pro- and antiapoptotic BCL-2-related proteins, …See details»
Bcl-2-family proteins: the role of the BH3 domain in …
Aug 1, 1998 Particularly intriguing is the emergence of the BH3 domain as a potent `death domain' and of a growing subclass of pro-apoptotic proteins with no similarity to Bcl-2 beyond their BH3 homology. ... Here, the authors classify …See details»
BH3-only proteins in apoptosis and beyond: an overview
Jul 30, 2009 BH3-only BCL-2 family proteins are effectors of canonical mitochondrial apoptosis. They discharge their pro-apoptotic functions through BH1–3 pro-apoptotic proteins such as …See details»
Bcl-2-family proteins: the role of the BH3 domain in apoptosis
Particularly intriguing is the emergence of the BH3 domain as a potent 'death domain' and of a growing subclass of pro-apoptotic proteins with no similarity to Bcl-2 beyond their BH3 …See details»
BH3-Only Proteins in Health and Disease - ScienceDirect
Jan 1, 2017 The BH3-only proteins are intrinsically disordered proteins and in the absence of binding to their partner protein(s), they exist at very high entropy levels—with the exception of …See details»
Bid chimeras indicate that most BH3-only proteins can directly …
A thorough understanding of BH3-only proteins is crucial for the development of cancer therapeutics such as the new class of anti-cancer molecules called BH3 mimetics that are …See details»
BH3-Triggered Structural Reorganization Drives the Activation of ...
Nov 12, 2010 BID was the first protein classified as a BCL-2 family member based solely on the presence of a homologous BH3 domain, and was discovered as a result of its dual interactions …See details»
Measurement of BH3-only protein tolerance - PMC
Anticancer drugs induce BH3-only protein upregulation. After Jurkat (left) and SKW6.4 (right) cells were treated with indicated concentrations of bortezomib (a), pevonedistat (pevoned; b), TAK …See details»
BH3 molecular geometry, lewis structure, hybridization, bond angle
Oct 10, 2023 Borane is also known as boron trihydride is an unstable and colorless gas with the chemical formula BH 3.It is a highly reactive molecule. In this tutorial, we will discuss Borane …See details»
What role does BH3 play in a chemical reaction? - Answers
Feb 7, 2025 BH3, or borane, acts as a Lewis acid in chemical reactions by accepting a pair of electrons from a Lewis base. This allows BH3 to participate in various reactions, such as …See details»
Exploiting BH3 Mimetic Drugs to Drive Apoptosis in Prostate Cancer
The team will also identify BH3 mimetic combination therapies that are effective in preclinical models of CRPC, as a strategy for expanding these treatments to have efficacy in more …See details»
BH3-Triggered Structural Reorganization Drives the Activation of …
Nov 12, 2010 The BH3 Trigger Converts BAX from a “Closed-loop” to an Activated “Open-loop” Conformation. NMR analysis of the BIM SAHB-BAX interaction identified significant changes …See details»