DOGMA THERAPEUTICS

The pharmaceutical industry has struggled to identify small molecule inhibitors of PCSK9 function. This has been explained by the expansive but flat binding interface between PCSK9 and the LDL receptor, spanning nearly 800 square angstroms. To date, only monoclonal antibodies have been able to target this region of PCSK9. We have discovered bona fide small molecule inhibitors of PCSK9 function that are orally bioavailable across multiple preclinical species. Guided by dozens of high-resolution x-ray structures of our molecules bound to PCSK9, we have utilized structure-based design to achieve picomolar affinity.

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DOGMA THERAPEUTICS

Industry:

Biotechnology Pharmaceutical

Founded:

2017-01-01

Address:

Boxford, Massachusetts, United States

Country:

United States

Website Url:

http://www.dogmatherapeutics.com

Total Employee:

Status:

Active

Email Addresses:

[email protected]

Total Funding:

3.5 M USD

Technology used in webpage:

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Current Employees Featured

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Doug Daniels
Doug Daniels Founder @ Dogma Therapeutics
Founder

Founder

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Doug Daniels

Investors List

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Official Site Inspections

http://www.dogmatherapeutics.com

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