EFFECTOR THERAPEUTICS

eFFECTOR is a clinical stage biopharmaceutical company focused on pioneering the development of a new class of oncology drugs referred to as selective translation regulator inhibitors (STRIs). eFFECTOR’s STRI product candidates target the eIF4F complex and its activating kinase, mitogen-activated protein kinase 1/2 (MNK 1/2). The eIF4F complex is a central node where two of the most frequently mutated signaling pathways in cancer, the PI3K-AKT and RAS-MEK pathways, converge to activate the tra... nslation of select messenger RNA into proteins that are frequent culprits in key disease driving processes. Each of eFFECTOR’s product candidates is designed to act on a single protein that drives the expression of multiple functionally related proteins, including oncoproteins and immunosuppressive proteins in T cells, that together control tumor growth, survival and immune evasion. eFFECTOR’s lead product candidate, tomivosertib, is a MNK 1/2 inhibitor. KICKSTART, a randomized, double-blind, placebo controlled Phase 2b trial of tomivorsertib in NSCLC in combination with pembrolizumab is currently open for enrollment. Zotatifin, eFFECTOR’s inhibitor of eIF4A, is currently in the dose-escalation portion of a Phase 1/2 trial, with Phase 2a expansion cohorts expected to initiate in the second half of 2021. eFFECTOR has a global collaboration with Pfizer to develop inhibitors of a third target, eIF4E.

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EFFECTOR THERAPEUTICS

Social Links:

Industry:

Biotechnology Health Care Medical

Founded:

2012-01-01

Address:

San Diego, California, United States

Country:

United States

Website Url:

http://www.effector.com

Total Employee:

11+

Status:

Active

Contact:

8589258215

Email Addresses:

[email protected]

Total Funding:

220.02 M USD

Technology used in webpage:

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Current Advisors List

jonathan-root_image

Jonathan Root Board of Directors @ Effector Therapeutics
Board_member

elaine-jones_image

Elaine Jones Board of Directors @ Effector Therapeutics
Board_member
2017-07-01

maha-katabi_image

Maha Katabi Board Member @ Effector Therapeutics
Board_member

Current Employees Featured

steve-worland_image

Steve Worland
Steve Worland President & CEO @ Effector Therapeutics
President & CEO
2012-01-01

not_available_image

Kevan Shokat
Kevan Shokat Founder @ Effector Therapeutics
Founder

douglas-warner_image

Douglas Warner
Douglas Warner Chief Medical Officer @ Effector Therapeutics
Chief Medical Officer
2022-08-01

alana-mcnulty_image

Alana McNulty
Alana McNulty Chief Business Officer and Chief Financial Officer @ Effector Therapeutics
Chief Business Officer and Chief Financial Officer

john-smither_image