FILGRASTIM AND PEGFILGRASTIM

Filgrastim and pegfilgrastim are a supportive part of treatment for many patients receiving cancer chemotherapy. Some cancer drugs, in addition to attacking the cancer, destroy the patient's white blood cells, which are extremely important in fighting infection. Consequently, these patients are prone to developing severe, and even life-threatening, infections. Filgrastim and pegfilgrastim restore the number of white blood cells and thus improve their ability to kill infecting micro-organisms.

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FILGRASTIM AND PEGFILGRASTIM

Industry:
Health Care Pharmaceutical

Address:
Zürich, Zurich, Switzerland

Country:
Switzerland

Status:
Active


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More informations about "Filgrastim and Pegfilgrastim"

A randomized, double‐blind trial of pegfilgrastim versus filgrastim …

Apr 12, 2016 Pegfilgrastim is a pegylated form of the granulocyte‐colony stimulating factor, filgrastim. Herein, we report the results of a multicentre, randomized, double‐blind phase III …See details»

Pegfilgrastim versus filgrastim after high-dose chemotherapy and ...

Nov 11, 2009 Pegfilgrastim (PEG) is synthesized by adding a 20 kDa polyethylene glycol moiety to FIL. This process modifies the pharmacokinetics and pharmacodynamic proprieties: longer …See details»

Pegfilgrastim versus filgrastim in the supportive care of …

May 25, 2020 Background: Pegfilgrastim is a pegylated long-acting recombinant form of G-CSF that extends the half-life and allows for once-per-cycle dosing, requiring less frequent dosing than nonpegylated G-CSF. The objective of this …See details»

Use of filgrastim and pegfilgrastim to support delivery of

The most recent guidelines from three international cancer organizations, the European Organization for Research and Treatment of Cancer, the American Society of Clinical …See details»

Pegfilgrastim: the promise of pegylation fulfilled

It is remarkable that all of this has occurred over the last decade since the initial approval of filgrastim (G-CSF) [].While much work remains to further our understanding of the biology and …See details»

Comparison of filgrastim and pegfilgrastim to prevent ... - PubMed

Purpose: The aim of this study was to compare the effectiveness of prophylactic single fixed dose of pegfilgrastim and daily administration of filgrastim on febrile neutropenia (FN), severe …See details»

Pegfilgrastim - StatPearls - NCBI Bookshelf

Apr 12, 2020 Pegfilgrastim is a pegylated granulocyte colony-stimulating factor that is FDA-approved to decrease the risk of patients developing febrile neutropenia when receiving myelosuppressive chemotherapy regimens. For …See details»

The Clinical Pharmacology of Filgrastim and Pegfilgrastim

Nov 15, 2011 Pharmacodynamic model describing the granulopoietic effects of pegfilgrastim. Serum concentrations of pegfilgrastim stimulate mitosis and mobilization of band cells and …See details»

Two decades of pegfilgrastim: what have we learned? Where do …

Apr 8, 2023 The administration of the first granulocyte colony-stimulating factor (G-CSF) filgrastim reduced the incidence and duration of FN in patients undergoing chemotherapy. …See details»

Cost-effectiveness of pegfilgrastim versus filgrastim for prevention …

Dec 30, 2022 Background Febrile neutropenia (FN) is a prevalent and potentially life-threatening complication in patients with lymphoma receiving myelosuppressive chemotherapy. …See details»

Comparative effectiveness of pegfilgrastim, filgrastim, and ...

Objective: Few studies have compared the effectiveness of filgrastim (FIL), pegfilgrastim (PEG), and sargramostim (SAR) to reduce the risk of febrile neutropenia (FN) associated with …See details»

Filgrastim - Wikipedia

Filgrastim, sold under the brand name Neupogen among others, is a medication used to treat low neutrophil count. [19] Low neutrophil counts may occur with HIV/AIDS, following …See details»

How to Give Yourself an Injection of Filgrastim (Neupogen®) or ...

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Pegfilgrastim - Wikipedia

Pegfilgrastim, sold under the brand name Neulasta among others, is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (GCSF) analog filgrastim. [17] It …See details»

Filgrastim - StatPearls - NCBI Bookshelf

Jul 3, 2023 Filgrastim is a medication used to manage and treat neutropenia in patients with myelosuppression from chemotherapy or radiation, which increases the risk of infection and related events. This activity outlines the indications, …See details»

Pegfilgrastim: Uses, Dosage, Side Effects, Warnings - Drugs.com

Jan 8, 2024 Pegfilgrastim is a pegylated or long-acting form of recombinant G-CSF, which means that it stays in your body for longer and doesn't need to be administered as often. …See details»

Pegfilgrastim (subcutaneous route) - Mayo Clinic

Jan 31, 2024 Pegfilgrastim injection is used to treat neutropenia (low white blood cells) that is caused by cancer medicines. It is a synthetic (man-made) form of a substance that is naturally …See details»

Pegfilgrastim: Uses, Interactions, Mechanism of Action - DrugBank …

Generic Name Pegfilgrastim DrugBank Accession Number DB00019 Background. Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) …See details»

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