uFluidix

Leukocyte differentiation and counting are critical for clinical diagnostics but are hindered by the low throughput and labor-intensive nature of traditional techniques. A recent study in the journal of Microsystems and Nanoengineering introduces a #microfluidic chip serving as an impedance flow cytometer to resolve that. Read more at https://lnkd.in/gx7EcjTc #microfluidics #labonachip #biotechnology #microfabrication

Warmest greetings and heartfelt wishes for a joyful and successful year ahead from all of us at uFluidix. We’ve had a remarkable time working together with our clients, partners, and colleagues, and we look forward to creating even more wonderful memories in the coming year! We’ll be closed until the new year—see you soon!

This week's research highlight is a study detailing a passive droplet #microfluidic platform for the screening of proteolytic microorganisms. The article explores a method that utilizes changes in droplet deformability, induced by microbial proteolysis, to enhance screening efficiency and throughput. Read more at https://lnkd.in/enCQeJH4 #Microfluidics #ProteolyticScreening #ScientificResearch #Biotech #Microfabrication #LabOnaChip

Understanding how cellular components, especially #chromatin and nuclear condensates, respond to mechanical forces during confined migration is crucial. This is particularly relevant in the context of cancer metastasis. Luckily, #microfluidics offers the exact right tool! Recent research published in Nature Communications provides insights into the mechanical stress effects on the nucleus, revealing how chromatin compaction and heterogeneity influence nuclear condensate dynamics. Read more at https://lnkd.in/g76VWz6k #Microfluidic #CellMigration #CancerResearch #Mechanobiology #BiomedicalEngineering #Biotechnology #Microfabrication #LabOnaChip

High-throughput droplet hashtag #microfluidics has transformed biological assays, but sorting accuracy can remain a challenge due to droplet size variability, especially in large libraries. A new microfluidic sorting method combines fluorescence and size-based selection to drastically reduce sorting errors. This development could enhance workflows in assays where both high accuracy and speed are critical. Read more at https://lnkd.in/gUWc2fYv #Microfluidics #DropletSorting #Biotechnology #LabOnaChip #Microfabrication #SingleCellAnalysis

Protein characterization plays an important role in understanding the mechanisms governing cellular functions. Traditional methods, while effective, often fall short when it comes to handling low-input samples or preserving the native states of protein complexes during analysis. A recent #microfluidic technique using engineered hydrogel beads is designed to address this. This method offers a significant advancement in maintaining the native state of proteins during analysis and proves essential for researchers studying complex biological processes. Read more at: https://lnkd.in/gZfkwmEb #ProteinAnalysis #Biochemistry #Microfluidics #Microfabrication #ProteinComplexes #LabOnaChip

Happy Canadian Thanksgiving from all of us here at uFluidix!🍁 Enjoy the long weekend with your family and friends!! 🦃🍂🌽🍎 #ThanksgivingDay

This week's research highlight on our blog discusses the development of single-molecule #microfluidic diffusional sizing (smMDS), a new method for measuring protein sizes directly in solution. Read more at https://lnkd.in/giSFixr3 #microfluidics #biotechnology #ProteinAnalysis #microfabrication #labonachip

Pancreatic cancer, notorious for its poor prognosis and rapid progression, remains a significant challenge in oncology. The complexity of pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), necessitates innovative research approaches to understand and combat this deadly disease. A recent #microfluidic platform aims at the development of stable tumor-on-a-chip models using polydopamine interfacial coating, offering new insights and potential pathways for therapeutic intervention. Read more at https://lnkd.in/gCZ4K3Xp #PancreaticCancer #CancerResearch #Microfluidics #LabOnaChip #OrganOnaChip #Biotechnology #Microfabrication

🔬 Exciting developments in neuroinflammation research using technology! Understanding how #microglia, the brain’s immune cells, respond to inflammation is important in understanding the complexities of neurological diseases. In a recent article published in Microsystems and Nanoengineering, a research team introduced a #microfluidic platform for monitoring calcium dynamics in microglia cells during neuroinflammation, aiming to improve the understanding of cellular behaviors under cytokine gradients. Read more at https://lnkd.in/gBXFDFxm #Neuroscience #Microfluidics #Neuroinflammation #Biotechnology #Microfabrication