Website: http://www.RXBIO.COM/
Develops proprietary compounds for mitigating acute radiation syndrome, focusing on gastrointestinal and hematological radiation syndrome, with lead compound Rx100 aiming to prevent radiation-induced death.
VentureRadar Research / Company Website
RxBio, Inc. is an early-stage pharmaceutical company. RxBio was formed around novel and proprietary, small-molecule technology developed at the University of Tennessee Health Science Center (UTHSC) in Memphis and licensed from the University of Tennessee Research Foundation (UTRF). The company's primary focus is the discovery and development of novel and proprietary compounds for use in the mitigation of acute radiation syndrome (ARS) – including gastrointestinal acute radiation syndrome (GI-ARS) as well as hematological radiation syndrome (HEM-ARS). Rx100 has shown significant efficacy for GI-ARS in both large and small animal models with survival as the endpoint. RxBio’s lead molecule, Rx100 is a metabolically stable analog of lysophosphatidic acid (LPA). Our preliminary data showed that Rx100 significantly inhibited toxin-induced and mediated secretory diarrhea. Rx100 could prove to be a very effective first line treatment strategy for prevention of diarrhea irrespective of the cause of diarrhea (enterotoxins, radiation, chemo, infection etc). RxBio has generated evidence that Rx100 and Rx300 series of compounds prevent gastric erosions and bleeding caused by nonsteroidal anti-inflammatory drugs (NSAID) such as aspirin and indomethacin. Rx compounds if taken in combination or after NSAID prevent erosions and bleeding in animal models of the human condition.
VentureRadar Research / Company Website
Associated sectors:
Biotechnology; Biotech;
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