MACROCYCLICS
Macrocyclics is a biotechnology research company that specializes in customized chelating agents and molecular innovation for medicine.
MACROCYCLICS
Social Links:
Industry:
Biotechnology Consulting Pharmaceutical
Founded:
1995-01-01
Address:
Plano, Texas, United States
Country:
United States
Website Url:
http://www.macrocyclics.com
Total Employee:
11+
Status:
Active
Contact:
+1 469 786-6060
Current Employees Featured
Official Site Inspections
http://www.macrocyclics.com Semrush global rank: 4.05 M Semrush visits lastest month: 3.02 K
- Host name: 141.193.213.10
- IP address: 141.193.213.10
- Location: United States
- Latitude: 37.751
- Longitude: -97.822
- Timezone: America/Chicago
More informations about "Macrocyclics"
Macrocyclics
Macrocyclics, Inc., a manufacturer of customized chelating agents, is dedicated to leading-edge development of new chelation chemistry platforms critical for advancement of diagnostic and …See details»
About Us - Macrocyclics
Macrocyclics, Inc., a manufacturer of customized chelating agents, is dedicated to leading-edge development of new chelation chemistry platforms critical for advancement of diagnostic and …See details»
Company History - Macrocyclics
Macrocyclics – A short history and future directions. Macrocyclics was founded in 1995 by Professor A. Dean Sherry as a result of his pioneering research in the development …See details»
Macrocyclization of linear molecules by deep learning to facilitate ...
Jul 28, 2023 · In this study, we propose a computational macrocyclization method based on Transformer architecture (which we name Macformer). Leveraging deep learning, Macformer …See details»
The exploration of macrocycles for drug discovery — an ... - Nature
Macrocyclic natural products have evolved to fulfil numerous biochemical functions, and their profound pharmacological properties have led to their development as drugs. A macrocycle …See details»
Introduction: Macrocycles | Chemical Reviews - ACS …
Sep 11, 2019 · They range from the macrocycles’ utility in drug discovery to their roles in catalysis, materials science, and sensing applications. Many functional characteristics of these enigmatic molecules arise from a delicate interplay of …See details»
Macrocyclic Chemistry: Current Trends and Future …
Written by well-known experts from around the world, the topics of the chapters range from new macrocyclic architectures with different functions and self-assembly processes through to the modeling and dynamics of such systems.See details»
Macrocycles: lessons from the distant past, recent …
While macrocycles have found use in many different areas of chemical science, it is the preorganization of binding elements in the course of a biologically relevant protein/ligand interaction that has been the topic of particularly intense efforts …See details»
Synthetic Opportunities and Challenges for …
Jun 2, 2021 · Therefore, we reviewed the past literature of drug-like macrocycles highlighting reactions that have been successfully used for the macrocyclization. We classified the cyclization reactions by their type, ring-size, yield, and …See details»
Macrocycles: lessons from the distant past, recent developments, …
Jan 1, 2015 · While macrocycles have found use in many different areas of chemical science, it is the preorganization of binding elements in the course of a biologically relevant protein/ligand …See details»
Julien Torgue, Ph.D. - Macrocyclics
His career started as a Project Manager at a Contract Manufacturing Organization, Goodwin Biotechnology, where he oversaw the development, production and regulatory filings of …See details»
Design, synthesis and applications of responsive macrocycles
Dec 17, 2020 · Inspired by the lock and key principle, the development of supramolecular macrocyclic chemistry has promoted the prosperous growth of host-guest chemistry. The …See details»
Macrocycles - Cambridge MedChem Consulting
May 5, 2019 · Many of the original macrocycles were developed from natural products and include peptide, polyketides, polyene and combinations, but more recently there has been …See details»
Online Catalog - Macrocyclics
Explore Macrocyclics' online catalog to find customized chelating agents for diagnostic and therapeutic medicine.See details»
Tools and rules for macrocycles | Nature Chemical Biology
Jul 20, 2014 · Recent studies advance our understanding of the way macrocycles bind protein targets and provide new strategies and tools to generate peptide-based macrocycles. …See details»
Macrocycles in Drug Discovery Learning from the Past for the Future
ABSTRACT: We have analyzed FDA-approved macrocyclic drugs, clinical candidates, and the recent literature to understand how macrocycles are used in drug discovery.See details»
Synthesis and direct assay of large macrocycle diversities by ...
Jul 2, 2022 · To overcome this, we herein established a combinatorial approach by tethering a myriad of chemical fragments to peripheral groups of structurally diverse macrocyclic scaffolds …See details»
Overview of Macrocycles in Clinical Development and Clinically Used
Aug 18, 2017 · This chapter presents a survey of the several macrocycles that have already been approved and used successfully as drugs and of the many macrocyclic compounds currently …See details»
How proteins bind macrocycles | Nature Chemical Biology
Jul 20, 2014 · There is little information, however, to guide the design of MCs for good target protein–binding activity or bioavailability. To address this knowledge gap, we analyze the …See details»
Contemporary strategies for peptide macrocyclization
Jun 23, 2011 · In this Review, we have considered emerging methods directed towards the syntheses of peptide macrocycles. These methods extend well beyond amide bond formation, …See details»