MICRO PRECISION
Micro Precision engages in the manufacturing and sales of devices centered on MEMS technology. The company was established in 2004.
MICRO PRECISION
Industry:
Machinery Manufacturing Manufacturing Product Design
Founded:
2004-01-01
Address:
Tokyo, Tokyo, Japan
Country:
Japan
Website Url:
http://www.mpc1.co.jp
Status:
Closed
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More informations about "Micro Precision"
Mitochondrial pyruvate carrier 1 - Wikipedia
Mitochondrial pyruvate carrier deficiency (MPYCD) is an autosomal recessive disease due to mutations in the MPC1 gene on chromosome 6q27. It is an inborn error of carbohydrate metabolism that blocks aerobic glycolysis by preventing the transport of pyruvate from the cytosol into the mitochondrion for … See moreSee details»
Mitochondrial Pyruvate Carrier Function in Health and Disease …
As a nodal mediator of pyruvate metabolism, the mitochondrial pyruvate carrier (MPC) plays a pivotal role in many physiological and pathological processes across the human lifespan, from …See details»
Heart failure—emerging roles for the mitochondrial pyruvate …
Jan 20, 2021 · In this review we discuss the evidence implicating the MPC as an important, perhaps causal, mediator of heart failure progression. Heart failure is a leading cause of death …See details»
The Pyruvate-Lactate Axis Modulates Cardiac Hypertrophy and …
Mar 2, 2021 · The mitochondrial pyruvate carrier (MPC) is a heterodimeric complex of MPC1 and MPC2 that transports pyruvate (Bricker et al., 2012), the product of glycolysis, into the …See details»
Human mitochondrial pyruvate carrier 2 as an autonomous …
Feb 22, 2018 · In contrast to MPC1, which co-purifies with a host chaperone, we demonstrated that MPC2 homo-oligomers promote efficient pyruvate transport into proteoliposomes. The …See details»
Mitochondrial pyruvate carrier abundance mediates pathological …
Oct 26, 2020 · Here we show that mitochondrial pyruvate carrier (MPC) abundance mediates pathological cardiac hypertrophy. MPC abundance was reduced in failing hypertrophic human …See details»
Structural Insights into the Human Mitochondrial …
Oct 19, 2021 · Here, we develop the de novo models of human MPC complexes and characterize the conformational dynamics of the MPC heterodimer formed by MPC1 and MPC2 (MPC1/2) by computational simulations.See details»
Mitochondrial pyruvate carrier 1: a novel prognostic biomarker …
May 31, 2021 · Mitochondrial pyruvate carrier 1 (MPC1) is a key metabolic protein that regulates the transport of pyruvate into the mitochondrial inner membrane. MPC1 deficiency may cause …See details»
Fifty years of the mitochondrial pyruvate carrier: New …
Jun 27, 2023 · In this review, we compile past and present findings on the structure, function and inhibition of the MPC as well as the therapeutic potential of MPC inhibition. The MPC is one of the major gatekeepers of pyruvate …See details»
Mitochondrial pyruvate transport regulates presynaptic …
Nov 15, 2024 · However, pyruvate passage through the inner mitochondrial membrane is facilitated by the mitochondrial pyruvate carrier (MPC), a multimeric complex of two subunits: …See details»
Protein structure - MPC1 - MPC1 - The Human Protein Atlas
General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene …See details»
Mitochondrial pyruvate import is a metabolic vulnerability in
Nov 19, 2018 · Here we show that the mitochondrial pyruvate carrier (MPC), a critical metabolic conduit linking cytosolic and mitochondrial metabolism, is transcriptionally regulated by AR.See details»
Mitochondrial pyruvate metabolism regulates the activation of …
Mar 1, 2023 · We show that quiescent NSPCs have an active mitochondrial metabolism and express high levels of MPC. Pharmacological MPC inhibition increases aspartate and triggers …See details»
MPC1 gene information - The Human Protein Atlas
The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner …See details»
PGC-1α promotes mitochondrial respiration and ... - ScienceDirect
Nov 1, 2021 · In this study, we found that peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) played an important role in inducing mitochondrial biogenesis and establishing …See details»
Mitochondrial pyruvate carrier 1 regulates ferroptosis in drug …
Jun 1, 2021 · MPC1 disruption increases mesenchymal marker expression, glutaminolysis, and ferroptosis. MPC1 inhibition increases ferroptosis susceptibility in vitro and in vivo. Cancer …See details»
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell …
Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvate oxidation. Here we find that deleting …See details»
The pyruvate-lactate axis modulates cardiac hypertrophy and heart ...
Dec 16, 2020 · We identify the mitochondrial pyruvate carrier (MPC) and the cellular lactate exporter monocarboxylate transporter 4 (MCT4) as pivotal nodes in this metabolic axis. We …See details»
Entry - *614738 - MITOCHONDRIAL PYRUVATE CARRIER 1; MPC1
In mitochondria, pyruvate is converted into acetyl-coenzyme A (acetyl-CoA) by the pyruvate dehydrogenase complex (see 300502). Uptake of pyruvate into mitochondria is mediated by a …See details»
MPC1 Gene - GeneCards | MPC1 Protein | MPC1 Antibody
Oct 2, 2024 · MPC1 (Mitochondrial Pyruvate Carrier 1) is a Protein Coding gene. Diseases associated with MPC1 include Mitochondrial Pyruvate Carrier Deficiency and Peripheral …See details»