PENTRAXIN THERAPEUTICS
Pentraxin Therapeutics Ltd is a University College London spin out company founded in 2001 by Professor Sir Mark Pepys FRS. In September 2011 Sir Mark retired as head of medicine at the Royal Free Campus of UCL and became the first Director of the new UCL Wolfson Drug Discovery Unit, which he created with funding from the Wolfson Foundation. Since 2012 the core funding of the Unit has been provided by the NIHR via its UCL/UCLH Biomedical Research Centre. Pentraxin holds the intellectual property and proprietary knowledge created by Sir Mark and his research group.
PENTRAXIN THERAPEUTICS
Industry:
Biotechnology Health Care Pharmaceutical Therapeutics
Founded:
2001-01-01
Address:
London, England, United Kingdom
Country:
United Kingdom
Website Url:
http://www.pentraxin.wordpress.com
Status:
Active
Email Addresses:
[email protected]
Similar Organizations
Astraea Therapeutics LLC
Astraea Therapeutics LLC is a discovery-stage pharmaceutical company
Cureab
cureab is a swiss based biotech company that was founded in 2012
Official Site Inspections
http://www.pentraxin.wordpress.com
- Host name: 192.0.78.12
- IP address: 192.0.78.12
- Location: San Francisco United States
- Latitude: 37.7506
- Longitude: -122.4121
- Metro Code: 807
- Timezone: America/Los_Angeles
- Postal: 94110
More informations about "Pentraxin Therapeutics"
Pentraxin Therapeutics - Crunchbase Company Profile & Funding
Pentraxin Therapeutics Ltd is a University College London spin out company founded in 2001 by Professor Sir Mark Pepys FRS. In September 2011 Sir Mark retired as head of medicine at the โฆSee details»
Pentraxin Therapeutics Ltd. - Drug pipelines, Patents, Clinical trials ...
Jun 10, 2024 Explore Pentraxin Therapeutics Ltd. with its drug pipeline, therapeutic area, technology platform, , Disease Domain:Endocrinology and Metabolic Disease, Technology ...See details»
Pentraxin Company Profile 2024: Valuation, Funding & Investors
Pentraxin General Information Description. Developer of drugs research platform intended to offer treatment of amyloidosis and amyloid-related diseases. The company's platform designs and โฆSee details»
Pentraxins - Wikipedia
Pentraxins are characterised by calcium dependent ligand binding and a distinctive flattened ฮฒ-jellyroll structure similar to that of the legume lectins. The name "pentraxin" is derived from the Greek word for five (ฯฮญฮฝฯฮต, pente) and axle (axis) relating to the radial symmetry of five monomers forming a ring approximately 95Å across and 35Å deep observed in the first members of this family to be identified. The "short" pentraxins include Serum Amyloid P component (SAP) and C reactive proteinSee details»
Pentraxin - an overview | ScienceDirect Topics
Pentraxins are a key component of the humoral innate immune system [2].In particular, because of the conservation in terms of structure and regulation, the long pentraxin PTX3 has provided โฆSee details»
Editorial: The Role of Pentraxins: From Inflammation, Tissue Repair โฆ
Dec 3, 2019 The latter are 25 kDa secreted proteins characterized by a structural organization in which five (CRP) or ten (SAP) identical protomers are assembled in a pentameric symmetry. โฆSee details»
Structural insights into the biological functions of the long โฆ
Oct 9, 2023 Amongst soluble PRMs, pentraxins are a family of highly conserved proteins with distinctive structural features. Originally identified in the early 1990s as an early inflammatory โฆSee details»
The Basic Characteristics of the Pentraxin Family and Their โฆ
The short pentraxins are comprised of C-reactive protein (CRP) and serum amyloid P component (SAP), whereas the long pentraxins are composed of neuronal pentraxin 1(NPTX1), neuronal โฆSee details»
Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory ...
Short pentraxins are about 25-kDa proteins sharing a common structural organization of five or ten subunits that are assembled in pentameric radial symmetry. The classical short pentraxins โฆSee details»
Organization, Structure and Expression of Pentraxin Genes - Springer
Organization, Structure and Expression of Pentraxin Genes A. S. Whitehead Introduction The acute phase response is a systemic reaction to an inflammatory stimulus (such as burns, โฆSee details»
Pentraxins - SpringerLink
Jan 1, 2017 Based on the primary structure, pentraxins are divided into two subfamilies: short and long pentraxins. Prototypes of the short pentraxin family are C-reactive protein (CRP, โฆSee details»
Structural insights into the biological functions of the long โฆ
A similar structural organization is found in serum amyloid P component (SAP) , another short pentraxin identified in the โ70s that shares with CRP calcium-dependent recognition of several โฆSee details»
Pentraxins: structure, function, and role in inflammation
Sep 14, 2013 The pentraxins are an ancient family of proteins with a unique architecture found as far back in evolution as the Horseshoe crab. In humans the two members of this family are โฆSee details»
The neuronal pentraxin Nptx2 regulates complement activity and ...
Peripheral pentraxins bind C1q with their pentraxin domain . To test whether C1q binds to the pentraxin domain of NPTXs, we expressed and purified Nptx2 pentraxin domain (X2-PD) and โฆSee details»
The structural organisation of pentraxin-3 and its ... - bioRxiv
Aug 14, 2024 Pentraxin-3 (PTX3) is an octameric protein, comprised of eight identical protomers, that has diverse functions in reproductive biology, innate immunity and cancer. โฆSee details»
Frontiers | Editorial: The Role of Pentraxins: From Inflammation ...
Pentraxins are a superfamily of highly conserved molecules characterized by a common structural motif, the so-called โpentraxin domainโ (1, 2).C reactive protein (CRP), originally identified for โฆSee details»
Evolution of the Pentraxin Family: The New Entry PTX4
May 1, 2010 C-reactive protein (CRP), which, together with serum amyloid P (SAP) component (APCS), constitutes the short pentraxin arm of the superfamily, was the first fluid-phase โฆSee details»
Pentraxin - an overview | ScienceDirect Topics
The short pentraxins include classical mammalian APPs such as CRP and SAP, which comprise solely the pentraxin domain. PTX3 belongs to the long pentraxins, which possess a second N โฆSee details»
PTX3 structure determination using a hybrid cryoelectron โฆ
The pentraxin family of proteins are a group of humoral pattern recognition molecules (PRMs) and comprise both short and long pentraxins ().The canonical long pentraxin PTX3 is expressed in โฆSee details»
The Basic Characteristics of the Pentraxin Family and Their โฆ
Aug 18, 2020 The pentraxin is a superfamily of proteins with the same domain known as the pentraxin domain at C-terminal. This family has two subgroups, namely; short pentraxins (C โฆSee details»