PENTRAXIN THERAPEUTICS
Pentraxin Therapeutics Ltd is a University College London spin out company founded in 2001 by Professor Sir Mark Pepys FRS. In September 2011 Sir Mark retired as head of medicine at the Royal Free Campus of UCL and became the first Director of the new UCL Wolfson Drug Discovery Unit, which he created with funding from the Wolfson Foundation. Since 2012 the core funding of the Unit has been provided by the NIHR via its UCL/UCLH Biomedical Research Centre. Pentraxin holds the intellectual property and proprietary knowledge created by Sir Mark and his research group.
PENTRAXIN THERAPEUTICS
Industry:
Biotechnology Health Care Pharmaceutical Therapeutics
Founded:
2001-01-01
Address:
London, England, United Kingdom
Country:
United Kingdom
Website Url:
http://www.pentraxin.wordpress.com
Status:
Active
Email Addresses:
[email protected]
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Official Site Inspections
http://www.pentraxin.wordpress.com
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- Latitude: 37.7506
- Longitude: -122.4121
- Metro Code: 807
- Timezone: America/Los_Angeles
- Postal: 94110
More informations about "Pentraxin Therapeutics"
Pentraxins - Wikipedia
Pentraxins are characterised by calcium dependent ligand binding and a distinctive flattened β-jellyroll structure similar to that of the legume lectins. The name "pentraxin" is derived from the Greek word for five (Ï€Îντε, pente) and axle (axis) relating to the radial symmetry of five monomers forming a ring approximately 95Å across and 35Å deep observed in the first members of this family to be identified. The "short" pentraxins include Serum Amyloid P component (SAP) and C reactive proteinSee details»
Pentraxin Therapeutics - Crunchbase Company Profile & Funding
Pentraxin Therapeutics Ltd is a University College London spin out company founded in 2001 by Professor Sir Mark Pepys FRS. In September 2011 Sir Mark retired as head of medicine at the …See details»
Organization, Structure and Expression of Pentraxin Genes - Springer
Organization, Structure and Expression of Pentraxin Genes A. S. Whitehead Introduction The acute phase response is a systemic reaction to an inflammatory stimulus (such as burns, …See details»
Structural insights into the biological functions of the long …
Oct 9, 2023 Amongst soluble PRMs, pentraxins are a family of highly conserved proteins with distinctive structural features. Originally identified in the early 1990s as an early inflammatory …See details»
Pentraxin - an overview | ScienceDirect Topics
Pentraxins are a key component of the humoral innate immune system [2].In particular, because of the conservation in terms of structure and regulation, the long pentraxin PTX3 has provided …See details»
The Basic Characteristics of the Pentraxin Family and Their …
The short pentraxins are comprised of C-reactive protein (CRP) and serum amyloid P component (SAP), whereas the long pentraxins are composed of neuronal pentraxin 1(NPTX1), neuronal …See details»
Pentraxins: Structure, Function, and Role in Inflammation
The long pentraxins include guinea pig apexin, neural pentraxin I (NPTXI) and II (NPTXII), and long pentraxin 3 (PTX3). PTX3, the best studied of these, activates complement, binds to …See details»
The pentraxins PTX3 and SAP in innate immunity, regulation of ...
Schematic representation of prototypes of the Pentraxin superfamily. Short pentraxins CRP and SAP are secreted proteins produced by hepatocytes in response to IL-6. They contain a …See details»
Pentraxins - SpringerLink
Jan 1, 2017 Based on the primary structure, pentraxins are divided into two subfamilies: short and long pentraxins. Prototypes of the short pentraxin family are C-reactive protein (CRP, …See details»
Pentraxin - an overview | ScienceDirect Topics
The short pentraxins include classical mammalian APPs such as CRP and SAP, which comprise solely the pentraxin domain. PTX3 belongs to the long pentraxins, which possess a second N …See details»
STRUCTURE AND PHYLOGENY OF PENTRAXINS - ijnrd.org
Pentraxins (PTXs) is a conserved protein superfamily that is part of the immune system and has large effectiveness in the immune mechanism. The proteins are thought to be practical …See details»
PTX3 - Wikipedia
Pentraxin-related protein PTX3 also known as TNF-inducible gene 14 protein (TSG-14) is a protein that in humans is encoded by the PTX3 gene. [5] [6]Pentraxin 3 (ptx3) is a member of …See details»
Progress in the study of pentraxin-3(PTX-3) as a biomarker for sepsis
Jul 3, 2024 2. Pentraxin-3(PTX-3) Pentraxins is an evolutionarily conserved protein superfamily characterized by a structural motif, that is, the pentraxin domain ().Pentraxin-3 is a 45 …See details»
Evolution of the Pentraxin Family: The New Entry PTX4
May 1, 2010 C-reactive protein (CRP), which, together with serum amyloid P (SAP) component (APCS), constitutes the short pentraxin arm of the superfamily, was the first fluid-phase …See details»
Pentraxin 3: A Novel Biomarker for Inflammatory Cardiovascular …
Early and transient release of leukocyte pentraxin 3 during acute myocardial infarction. Journal of Immunology. 2011;187(2):970–979. doi: 10.4049/jimmunol.1100261. [Google Scholar] 29. …See details»
Molecular insight into pentraxin-3: Update advances in innate …
Dec 1, 2022 Pentraxins are a family of evolutionarily highly conserved proteins characterized by a cyclic multimeric structure [1], [2].Besides, pentraxins belong to soluble pattern recognition …See details»
Pentraxins in the Activation and Regulation of Innate Immunity
Key structural features. The human PTX3 is a homo-multimeric glycoprotein, whose protomer subunits comprise 381 amino acids, including a 17 residue long leader peptide (Fig. 1A).The …See details»
Pentraxins: structure, function, and role in inflammation
Sep 14, 2013 The pentraxins are an ancient family of proteins with a unique architecture found as far back in evolution as the Horseshoe crab. In humans the two members of this family are …See details»