PROTEOSTASIS THERAPEUTICS
Proteostasis Therapeutics is discovering and developing novel small molecule therapeutics designed to control the body's protein homeostasis, or Proteostasis Network. The Proteostasis Network maintains the body's natural balance of proteins to protect us from numerous diseases. These novel therapies, or Proteostasis Regulators, are designed to treat multiple genetic and degenerative disorders associated with deficiencies of the Proteostasis Network, such as emphysema, type II diabetes, Alzheimer's Disease and Huntington's Disease.
PROTEOSTASIS THERAPEUTICS
Industry:
Biotechnology Medical Therapeutics
Founded:
2007-01-01
Address:
Cambridge, Massachusetts, United States
Country:
United States
Website Url:
http://www.proteostasis.com
Total Employee:
51+
Status:
Active
Contact:
6172257801
Email Addresses:
[email protected]
Total Funding:
105.01 M USD
Technology used in webpage:
SPF Domain Not Resolving Microsoft Exchange Online Office 365 Mail IPv6 ReCAPTCHA V2 Microsoft GlobalSign GlobalSign Domain Verification Akamai Hosted
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Current Advisors List
Current Employees Featured
Founder
Stock Details
Investors List
Cormorant Asset Management
Cormorant Asset Management investment in Series B - Proteostasis Therapeutics
Sanofi Ventures
Sanofi Ventures investment in Series B - Proteostasis Therapeutics
Novartis Venture Fund
Novartis Venture Fund investment in Series B - Proteostasis Therapeutics
HealthCare Ventures
HealthCare Ventures investment in Series B - Proteostasis Therapeutics
F-Prime Capital
F-Prime Capital investment in Series B - Proteostasis Therapeutics
Rock Springs Capital
Rock Springs Capital investment in Series B - Proteostasis Therapeutics
New Enterprise Associates
New Enterprise Associates investment in Series B - Proteostasis Therapeutics
Elan Corporation
Elan Corporation investment in Venture Round - Proteostasis Therapeutics
HealthCare Ventures
HealthCare Ventures investment in Series A - Proteostasis Therapeutics
Novartis Venture Fund
Novartis Venture Fund investment in Series A - Proteostasis Therapeutics
Official Site Inspections
http://www.proteostasis.com
- Host name: apache2-dap.pdx1-shared-a1-36.dreamhost.com
- IP address: 69.163.180.60
- Location: Brea United States
- Latitude: 33.9339
- Longitude: -117.8854
- Metro Code: 803
- Timezone: America/Los_Angeles
- Postal: 92821
More informations about "Proteostasis Therapeutics"
Proteostasis Consortium – Proteostasis Consortium
The Proteostasis Consortium is a group of investigators who have worked together on proteostasis in biology, health, and diseases. Together, we have contributed fundamental insights on biochemical mechanisms of protein …See details»
The proteostasis network and its decline in ageing - Nature
Feb 7, 2019 This proteostasis network declines with age, which can be linked to human degenerative diseases. ... Understanding the organization of this network and its regulation in …See details»
Diversity in the origins of proteostasis networks - Nature
Mar 6, 2013 This proteostasis network has co-evolved with the proteome and is thought to play a part in driving evolution. ... Describes the fundamental role of HSP90 in directing the …See details»
Proteostasis - Wikipedia
Proteostasis is the dynamic regulation of a balanced, functional proteome. The proteostasis network includes competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking, and degradation of proteins present within and outside the cell. Loss of proteostasis is central to understanding the cause of diseases associated with excessive protein misfolding and degradation leading to loss-of-function phenotypes, as well as aggregation-associ…See details»
PROTEOSTASIS: A European Network to Break Barriers and …
May 1, 2019 Whether from the academic or the private sector, the PROTEOSTASIS network helped scientists to develop fundamental or translational research thanks to the multiple …See details»
Surfaceome dynamics reveal proteostasis-independent ... - Nature
Oct 5, 2020 Neurons are highly compartmentalized cells with tightly controlled subcellular protein organization. While brain transcriptome, connectome and global proteome maps are …See details»
Proteostasis: From translation to degradation - EMBO
Sep 1, 2023 This third edition of the EMBO workshop on Proteostasis focuses on promoting an integrated understanding of the proteostasis network.The proteostasis network is the collection of biological mechanisms that assure …See details»
Pathways of cellular proteostasis in aging and disease - PMC
Klaips et al. outline the pathways and molecular mechanisms of cellular protein homeostasis, or proteostasis, and discuss how a decline in proteostasis during aging contributes to disease. ...See details»
Functional Modules of the Proteostasis Network - PMC
Chaperones serve as the main conductors of proteostasis by directly influencing the “foldedness” of the proteome. They typically do so by binding to hydrophobic polypeptide segments that are …See details»
PROTEOSTASIS: A European Network to Break Barriers …
Feb 15, 2019 Protein homeostasis (proteostasis) is at the core of cellular functions. The European network PROTEOSTASIS was created to steer research and foster collaborations in the interconnected fields of posttranslational …See details»
Relationships between protein degradation, cellular senescence, …
Feb 13, 2024 Aging is a major risk factor for many diseases. Recent studies have shown that age-related disruption of proteostasis leads to the accumulation of abnormal proteins and that …See details»
Translation is an emerging constraint on protein homeostasis in …
Feb 28, 2024 The task of maintaining proteostasis within a cell is handled by the proteostasis network (PN) – in human cells, this has been defined as a set of approximately 2000 proteins …See details»
Proteostasis, oxidative stress and aging - PMC - PubMed Central …
Abstract. The production of reactive species is an inevitable by-product of metabolism and thus, life itself. Since reactive species are able to damage cellular structures, especially proteins, as …See details»
Build-UPS and break-downs: metabolism impacts on proteostasis …
Jan 4, 2021 Proteostasis surveillance mechanisms. The composition and functional integrity of the cellular proteome is under constant surveillance to maintain a balanced state of proteostasis.See details»
Proteostatic regulation in neuronal compartments - Cell Press
Sep 3, 2021 Neurons continuously adapt to external cues and challenges, including stimulation, plasticity-inducing signals and aging. These adaptations are critical for neuronal physiology …See details»
Protein Folding and Mechanisms of Proteostasis - PMC
This breakdown of proteostasis [89,91] can lead to a situation that is known as protein metastasis, ... The organization and evolutionary dynamics of the proteome provide a line of defense in …See details»
Golgi organization is regulated by proteasomal degradation
Jan 21, 2020 The Golgi is a dynamic organelle whose correct assembly is crucial for cellular homeostasis. Perturbations in Golgi structure are associated with numerous disorders from …See details»
Adapting the proteostasis capacity to sustain brain healthspan
Mar 9, 2021 The proteostasis network is able to modulate the abundancy of all these abnormal species by different mechanisms. Misfolded protein can be degraded by CMA, whereas large …See details»
Proteostasis and aging - Nature Medicine
Dec 8, 2015 Shortly afterwards, it was demonstrated that tele-proteostasis applies to both cytosolic and organelle proteostasis, and also, that the robustness of tele-proteostasis is an …See details»
Relationships between protein degradation, cellular senescence, …
Feb 13, 2024 Abstract. Aging is a major risk factor for many diseases. Recent studies have shown that age-related disruption of proteostasis leads to the accumulation of abnormal …See details»