RHDL THERAPEUTICS
RHDL Therapeutics develops a nanoparticulate drug delivery platform to deliver a therapeutic payload of RNA for disease indications. The platform harnesses the bodyโs cholesterol delivery mechanisms by artificially reconstituting high-density lipoproteins (HDL). The RHDL particles are protected from the bodyโs natural defense mechanisms, exhibit prolonged circulation time, and are generally non-toxic in humans. RHDL's technology is being developed through a scientific partnership with teams from MD Anderson Cancer Center and the University of North Texas Health Science Center.
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More informations about "rHDL Therapeutics"
rHDL Therapeutics - Drug pipelines, Patents, Clinical trials - Synapse
Last update 02 May 2024. rHDL Therapeutics. Private CompanySee details»
Reconstituted HDL: Drug Delivery Platform for Overcoming โฆ
Oct 15, 2018 These platforms have been used for drug delivery, siRNA delivery, and modulating cellular cholesterol levels. The rHDL NPs, Apo A-1 protein, and its mimetic peptides are also โฆSee details»
Reconstituted HDL as a therapeutic delivery device - PMC
Nov 2, 2024 The relative ease with which discoidal rHDL can be generated in vitro has led to novel applications including a) infusion of rHDL into patients to promote regression of โฆSee details»
rHDL Therapeutics - Crunchbase
RHDL Therapeutics develops a nanoparticulate drug delivery platform to deliver a therapeutic payload of RNA for disease indications.See details»
HDL as a drug and nucleic acid delivery vehicle - PMC
The rHDL drug delivery model may have particularly important applications in cancer therapeutics because of the potential for tumor selective delivery of anti-cancer agents (Shahzad et al., โฆSee details»
Reconstituted high-density lipoproteins: novel biomimetic โฆ
Jan 1, 2018 High-density lipoproteins (HDL) are dynamic natural nanoparticles that are composed of diverse biological macromolecules. Many aspects of the nanoparticles such as โฆSee details»
Pathways by Which Reconstituted High-Density โฆ
Dec 17, 2009 Objectiveโ Reconstituted high-density lipoprotein (rHDL) is of interest as a potential novel therapy for atherosclerosis because of its ability to promote free cholesterol (FC) mobilization after intravenous administration. โฆSee details»
Reconstituted high density lipoprotein (rHDL), a โฆ
RHDL is a synthesized drug delivery nanoplatform exhibiting excellent biocompatibility, which possesses most of the advantages of HDL. rHDL shows almost no toxicity and can be degraded to non-toxic substances in vivo.The โฆSee details»
Reconstituted HDL: Drug Delivery Platform for Overcoming
Oct 15, 2018 This highly robust drug transport system provides site-specific, tumor-selective delivery of anti-cancer agents while reducing harmful off-target effects. Utilizing rHDL NPs for โฆSee details»
Reconstituted high-density lipoproteins: novel biomimetic โฆ
Dec 24, 2017 ApoA-I is the most abundant protein in plasma HDL, and apoA-I/apoA-I mimetic peptides are most commonly used for the construction of rHDL. rHDL particles which contain โฆSee details»
Direct cytosolic siRNA delivery by reconstituted high density ...
Stably assembled rHDL/Chol-siRNA complexes demonstrated proper nanosize, quasi-spherical shape and improved nuclease protection over naked Chol-siRNA. It was also interesting to โฆSee details»
HDL as Therapeutic Tools - SpringerLink
May 28, 2019 Classically, rHDL has been studied from the viewpoint of antiatherosclerotic therapies. In addition, however, to its demonstrated advantageous effects on HDL as โฆSee details»
Evaluation of reconstituted high-density lipoprotein (rHDL) as a โฆ
During the last decade, and with increasing intensity, the potential for using reconstituted high-density lipoprotein (rHDL) particles to deliver hydrophobic drugs to impaired cells and tissues โฆSee details»
Evaluation of reconstituted high-density lipoprotein (rHDL) as a โฆ
Oct 1, 2016 In addition, HDL has shown to induce anti-apoptotic behavior of beta-cells 23 and also stimulate insulin secretion. 24 Thus by combining the rHDL-associated positive effect on โฆSee details»
HDL Therapeutics - Crunchbase Company Profile & Funding
HDL Therapeutics may be growing as it is involved in a merger with a company that has an FDA-approved cardiovascular therapy, indicating an expansion of its business operations and โฆSee details»
Reconstituted HDL as a therapeutic delivery device - PMC
Nov 1, 2022 2. Reconstituted high density lipoprotein. As our understanding of nascent pre-ฮฒ HDL biogenesis in vivo evolved, it was discovered that isolated apoA-I possesses an intrinsic โฆSee details»
Reconstituted high density lipoprotein (rHDL), a versatile drug ...
Jan 28, 2021 rHDL is a synthesized drug delivery nanoplatform exhibiting excellent biocompatibility, which possesses most of the advantages of HDL. rHDL shows almost no โฆSee details»
Reconstituted HDL as a therapeutic delivery device
Nov 1, 2021 As our understanding of nascent pre-ฮฒ HDL biogenesis in vivo evolved, it was discovered that isolated apoA-I possesses an intrinsic ability to transform aqueous โฆSee details»
High density lipoprotein complexes as delivery vehicles for โฆ
Materials and methods: Recombinant high density lipoprotein (rHDL) particles were prepared with defined composition (phosphatidylcholine, apolipoprotein A-1, cholesterol and cholesteryl โฆSee details»