THE MAIN DOMAIN
THE MAIN DOMAIN
Industry:
Internet Web Hosting
Address:
Norwich, Norfolk, United Kingdom
Country:
United Kingdom
Website Url:
http://www.tmdi.net
Total Employee:
1+
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Active
Contact:
44-1603 402209
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[email protected]
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http://www.tmdi.net
- Host name: 74-208-236-163.elastic-ssl.ui-r.com
- IP address: 74.208.236.163
- Location: United States
- Latitude: 37.751
- Longitude: -97.822
- Timezone: America/Chicago
More informations about "The Main Domain"
Kadcyla (T-DM1): What to Expect, Side Effects, and More
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The Folding Pathway of ABC Transporter CFTR: Effective and Robust
Jul 15, 2024 TMD1 is the most N-terminal domain, translated first and co-translationally inserted into the ER membrane (image 1, based on structural model). 178 Its far N-terminus lacks …See details»
Cystic Fibrosis Transmembrane Conductance Regulator …
Structural organization of the CFTR domains. Cartoon representation of the homology models built using the structure of TM(287–288) (A), ABC-B10 (B), McjD (C), and Sav1866 (D). TMD1 (transmembrane helices 1–6) and NBD1 …See details»
The EMA review of trastuzumab emtansine (T-DM1) for …
Feb 26, 2021 Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate of trastuzumab [a monoclonal antibody against human epidermal growth factor receptor 2 (HER2)] and DM1 (an inhibitor of tubulin polymerisation). It was …See details»
Kadcyla (Ado-trastuzumab emtansine) - Massachusetts General …
4 Side Effects of Kadcyla (ado-trastuzumab emtansine) Common • Fatigue, nausea, constipation, low platelet counts (include nose bleeds or easy bleeding/bruising),See details»
Organic Synthesis and Current Understanding of the …
A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS ... Although the first site on TMD1 was uniquely identified to elexacaftor, ... Shaughnessy C.A., Zeitlin P.L., Bratcher …See details»
Mechanism of CFTR correction by type I folding correctors - Cell …
Mechanism in which the correctors stabilize TMD1 at an early stage of biogenesis, prevent its premature degradation, and thereby allosterically rescuing many disease-causing mutations. …See details»
Structural organization and interactions of transmembrane …
A model of the organization of a tetraspanin dimer. Two interfaces, the intramolecular TM1/TM2 and intermolecular TM1-TM2/TM1-TM2, have been analysed in this work. A third interface, …See details»
Organization and predicted secondary structures of CFTR TMD1 ...
A schematic representing the five domains of CFTR and the six putative transmembrane subdomains (m1-m6) of TMD1 is presented. Results from each of five secondary structure …See details»
Co-Translational Folding of the First Transmembrane Domain of …
Jun 25, 2021 This also explains why VX-809, which improves co-translational TMD1 folding, does not have any impact on NBD1 folding and stability as shown by our protease …See details»
ABC-transporter CFTR folds with high fidelity through a modular ...
Jan 7, 2023 E1–22 and TMD1C immunoprecipitated TMD1 linked to TMD2 and TMD1 expressed on its own (Fig. 1 d), similar to in-vitro translated TMD1 (Fig. 1 b). TMD2C and I4N …See details»
Transmembrane Domain Recognition during Membrane Protein …
Apr 23, 2018 The cavity is sealed laterally by TMD1 from a neighbouring Hrd1 molecule and lumenally by a two-layer seal of hydrophobic residues. Although the functional state …See details»
Structure and metal ion binding of the first transmembrane …
Jun 1, 2011 The extension of the Nt-TMD1 to the N-terminal end of TMD2 (Nt-TMD1-loop1/2) recovers the structure of the extended segment-helix and results in the coordination to Co 2+ …See details»
T-DM1 Approval Expanded for HER2-Positive Breast Cancer
May 23, 2019 The Food and Drug Administration (FDA) has expanded the approved use of the drug ado-trastuzumab emtansine (Kadcyla) to treat some women with HER2-positive breast …See details»
Redefining Hypo- and Hyper-Responding Phenotypes of CFTR …
VX-809 improves total CFTR and cell-surface levels of hypo-responding CF-causing mutants. (A) Cartoon of CFTR cryo-EM structure (PDB: 5UAK) and location of CF-causing mutations in …See details»
Mechanism of CFTR correction by type I folding correctors
Small molecule chaperones have been exploited as therapeutics for the hundreds of diseases caused by protein misfolding. The most successful examples are the CFTR correctors, which …See details»
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The ORMs interact with transmembrane domain 1 of Lcb1 and …
Mar 1, 2019 The lack of interaction between Lcb1∆TMD1-Cub and the Nub-tagged ORM proteins cannot be attributed to a general perturbation of Lcb1 since both the full-length and …See details»
Polio outbreak confirmed in PNG, World Health Organization says
1 day ago The World Health Organization (WHO) has confirmed a polio outbreak in Papua New Guinea after diagnosing the virus in two healthy children. Poliovirus type 2 was detected in …See details»
The role of thrombomodulin lectin-like domain in inflammation
Mar 27, 2012 TMD1 consists of the first 1-155 amino acid residues in the N-terminal region of TM. There is a homology between TMD1 and the C-type lectin family. ... Thrombin-induced …See details»